Keith Melancon, MD, FACS discusses how ABO incompatible kidney transplant can now allow transplants between some individuals with different blood types. He shares the importance of the immunology of transplantation. and how desensitization, a process in which antibodies are removed from the blood through plasma exchange, can help to prevent antibodies from coming back. Additionally, he highlights hepatitis C transplantation and when to refer to the specialists at The George Washington University Hospital.