Can depression contribute to a heart attack?Depression and loneliness put a terrible strain on the heart, and not just in the emotional sense: Psychological distress can turn a survivor of heart disease into a victim.Depression may even help heart disease get its start.Several studies have suggested that depressed people who are otherwise healthy are more likely to develop heart disease than peers who aren't depressed.Laura B. Huff, PA-C is here to discuss how depression may contribute to heart attacks.