Heartburn is the most important risk factor for the most common type of esophageal cancer. Over time, gastroesophageal reflux disease can cause inflammation of the lining of the esophagus. If there is enough inflammation, the normal lining is replaced with an abnormal lining, called Barrett’s esophagus. In some cases, Barrett’s esophagus can then lead to esophageal cancer.Esophageal cancer is often at an advanced stage upon diagnosis, so treatment needs to be rapid and aggressive, requiring the expertise of specialists who are experienced in treating the disease.James L. Lin, MD is here to discuss esophageal cancer, it's diagnoses and treatments, and why City of Hope is leading the way.