EP 1,008B - Mechanisms That Make Skin A Protective Barrier

A Mount Sinai research team has identified one of the mechanisms that establish the skin as a protective barrier, a breakthrough that is critical to understanding and treating common skin conditions including eczema and psoriasis.

One of the most important roles of the skin is to act as a barrier that prevents water loss and protects the skin from pathogens. Failure of this protective function contributes to dermatological diseases. The research team led by Sarah E. Millar, Ph.D., Director of the Black Family Stem Cell Institute at the Icahn School of Medicine at Mount Sinai, found that the scaffolding protein,  histone deacetylase 3 (HDAC3), is essential for proper skin development and barrier formation.

Dr. Millar joins Dr. Roizen to talk about her team's findings and what they mean for those suffering from some skin conditions. 

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EP 1,008B - Mechanisms That Make Skin A Protective Barrier
Featuring:
Sarah E. Millar, Ph.D.
Sarah E. Millar, Ph.D. is Director of the Black Family Stem Cell Institute, and Lillian and Henry M. Stratton Professorial Chair in the Departments of Cell, Developmental and Regenerative Biology and Dermatology at the Icahn School of Medicine at Mount Sinai. Her research focuses on the roles of Wnt signaling and epigenetic regulatory mechanisms in the development and regeneration of the skin and its appendages. She is an Editorial Board member for Developmental Cell and Experimental Dermatology, and Deputy Editor for the Journal of Investigative Dermatology. Dr. Millar has received several awards in recognition of her research, including an NIH MERIT Award for her work on Wnt signaling in the skin, and the 2017 William Montagna Lectureship Award of the Society for Investigative Dermatology. 
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